Colorectal cancer (CRC) is the second leading cause of cancer death in the United States, with more than 50 000 deaths expected in 2017. Screening can reduce CRC mortality, and several methods of screening are available and recommended for average-risk adults aged 50 years to 75 years. Modeling studies suggest that several different methods of screening produce relatively similar levels of mortality reduction if there is good adherence to the underlying screening program.