Novel small antibody fragment: A valuable tool in crystallography

(Osaka University) Achieving quality diffracting crystals remains the major bottleneck in macromolecular X-ray crystallography. Antibody fragments have been used to aid structural analysis of complex macromolecules that are otherwise crystallization-resistant. However, there are issues such as stability, compatibility, and cost. Osaka University researchers succeeded in creating a novel antibody fragment termed ‘Fv-clasp,’ which exhibits enhanced stability and crystallizability. Furthermore, the scalability and affordability of the production process means Fv-clasp may be feasible for industrial applications.