Newly ID’d role of major Alzheimer’s gene suggests possible therapeutic target

A new role has been identified for the major Alzheimer’s risk factor ApoE4, suggesting that targeting the protein may help treat the disease. Researchers show that ApoE4 exacerbates the brain damage caused by toxic tangles of a different Alzheimer’s-associated protein: tau. In the absence of ApoE, tau tangles did very little harm to brain cells.