Close to 70 percent of men with erectile dysfunction (ED) respond to the ED drug sildenafil. However, only about 50 percent of men with diabetes–a population commonly affected by ED–achieve positive results with sildenafil. Researchers from the Smooth Muscle Research Centre at the Dundalk Institute of Technology, in Dundalk, Ireland, are studying two new drugs that may give men with diabetes–and others for whom conventional treatment is ineffective–new hope for treating ED.