Multi-mechanism approach to treating neonatal hypoxic ischemia

(Medical University of South Carolina) Male sex is a risk factor for worse outcome following neonatal insult, including hypoxic ischemia. While N-acetylcysteine and hypothermia promote functional improvement in female rodents, similar improvement in males requires the addition of vitamin D, report investigators at the Medical University of South Carolina in the September 1, 2017 issue of Neuropharmacology. Multi-mechanism approaches are needed to treat neonatal hypoxic ischemia, and those approaches appear to be different depending on sex.