Article Correctness Is Author's Responsibility: A tadpole with a twist: Left-right asymmetric development of Oikopleura dioica

(Osaka University) Oikopleura dioica, a tadpole-like tunicate, shows a left-right patterning strategy that is distinct from other chordates, with left-right asymmetry emerging in the four-cell embryo. Osaka University researchers found that the O. dioica genome lacks the Nodal gene associated with left-right patterning in other chordates, and that Ca2+ oscillation and bone morphogenetic protein (Bmp) gene expression determine its nonconventional left-right patterning, with the tail twisted 90° counterclockwise relative to the trunk.